Human LAPTM4B Recombinant Protein (N-GST & C-His) (HC812012)

Name: Human LAPTM4B Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HC812012
Price: 211 USD
Availability: InStock

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1mg

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Каталожный номер	HC812012
Описание	Recombinant Human LAPTM4B Protein, N-GST & C-His (HC812012) expressed in E. coli, spanning Thr2-Thr116. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q86VI4
Длина белка	Thr2-Thr116
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	40.65 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	LAPTM4B, Lysosomal-associated transmembrane protein 4B, Lysosome-associated transmembrane protein 4-beta
Фон	Lysosomal-associated transmembrane protein 4B is a ~35 kDa protein. Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. 1. Vergarajauregui, S. et al. (2011) Journal of cell science 124, 459-68. PMID: 21224396 2. Tan, X. et al. (2015) The EMBO journal 34, 475-90. PMID: 25588945 3. Milkereit, R. et al. (2015) Nature communications 6, 7250. PMID: 25998567 4. Huygens, C. et al. (2015) The Journal of biological chemistry 290, 20105-16. PMID: 26126825 5. Blom, T. et al. (2015) Nature chemical biology 11, 799-806. PMID: 26280656
Примечание	For research use only

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Human LAPTM4B Recombinant Protein (N-GST & C-His).pdf

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