Human LATS2 Recombinant Protein (N-His) (HD734012)

Name: Human LATS2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD734012
Price: 211 USD
Availability: InStock

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Número de catálogo	HD734012
Descripción	Recombinant Human LATS2 Protein, N-His (HD734012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q9NRM7
Longitud de proteína	Lys665-Ala1036
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	EC:2.7.11.1, KPM, Kinase phosphorylated during mitosis protein, LATS2, Large tumor suppressor homolog 2, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase kpm, Warts-like kinase
Fondo	Serine/threonine-protein kinase LATS2 is a ~120 kDa protein. Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. 1. Hao, Y. et al. (2008) The Journal of biological chemistry 283, 5496-509. PMID: 18158288 2. Meng, Z. et al. (2015) Nature communications 6, 8357. PMID: 26437443 3. Kim, M. et al. (2016) EMBO reports 17, 64-78. PMID: 26598551 4. Hwang, D. et al. (2021) Life science alliance 4. PMID: 34404733 8. Zhang, K. et al. (2012) The EMBO journal 31, 29-43. PMID: 21952048 9. Nie, L. et al. (2024) Molecular cell 84, 3336-3353.e7. PMID: 39173637
Nota	For research use only

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Datasheet

Human LATS2 Recombinant Protein (N-His).pdf

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