Human LATS2 Recombinant Protein (N-His) (HD734012)

Name: Human LATS2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD734012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD734012
Description	Recombinant Human LATS2 Protein, N-His (HD734012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q9NRM7
Longueur de protéine	Lys665-Ala1036
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	EC:2.7.11.1, KPM, Kinase phosphorylated during mitosis protein, LATS2, Large tumor suppressor homolog 2, Serine/threonine-protein kinase LATS2, Serine/threonine-protein kinase kpm, Warts-like kinase
Contexte	Serine/threonine-protein kinase LATS2 is a ~120 kDa protein. Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. 1. Hao, Y. et al. (2008) The Journal of biological chemistry 283, 5496-509. PMID: 18158288 2. Meng, Z. et al. (2015) Nature communications 6, 8357. PMID: 26437443 3. Kim, M. et al. (2016) EMBO reports 17, 64-78. PMID: 26598551 4. Hwang, D. et al. (2021) Life science alliance 4. PMID: 34404733 8. Zhang, K. et al. (2012) The EMBO journal 31, 29-43. PMID: 21952048 9. Nie, L. et al. (2024) Molecular cell 84, 3336-3353.e7. PMID: 39173637
Note	For research use only

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Human LATS2 Recombinant Protein (N-His).pdf

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