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| カタログ番号 | HD221012 |
|---|---|
| 説明 |
Recombinant Human LPIN1 Protein, N-His (HD221012) expressed in E. coli, spanning Asn621-Pro851. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q14693 |
| タンパク質長 | Asn621-Pro851 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 28.53 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:3.1.3.4, KIAA0188, LPIN1, Lipin-1, Phosphatidate phosphatase LPIN1 |
| 背景 | Phosphatidate phosphatase LPIN1 is a ~98 kDa protein. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels. Is involved in adipocyte differentiation. Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. 1. Han, GS. et al. (2010) The Journal of biological chemistry 285, 14628-38. PMID: 20231281 2. Eaton, JM. et al. (2013) The Journal of biological chemistry 288, 9933-9945. PMID: 23426360 3. Li, TY. et al. (2018) Nature communications 9, 1916. PMID: 29765047 4. MacVicar, T. et al. (2019) Nature 575, 361-365. PMID: 31695197 |
| 注意事項 | For research use only |
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