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| カタログ番号 | HC968012 |
|---|---|
| 説明 |
Recombinant Human LTN1 Protein, N-His (HC968012) expressed in E. coli, spanning Glu1587-Phe1766. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O94822 |
| タンパク質長 | Glu1587-Phe1766 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 22.96 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | C21orf10, C21orf98, E3 ubiquitin-protein ligase listerin, EC:2.3.2.27, KIAA0714, LTN1, RING finger protein 160, RING-type E3 ubiquitin transferase listerin, RNF160, ZNF294, Zinc finger protein 294 |
| 背景 | E3 ubiquitin-protein ligase listerin is a ~200 kDa protein. E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains. Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product. 1. Shao, S. et al. (2013) Molecular cell 50, 637-48. PMID: 23685075 2. Shao, S. et al. (2014) Molecular cell 55, 880-890. PMID: 25132172 3. Shao, S. et al. (2015) Molecular cell 57, 433-44. PMID: 25578875 4. Matsuo, Y. et al. (2017) Nature communications 8, 159. PMID: 28757607 |
| 注意事項 | For research use only |
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