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| カタログ番号 | HD905012 |
|---|---|
| 説明 |
Recombinant Human MARCHF1 Protein, N-His (HD905012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q8TCQ1 |
| タンパク質長 | Met1-Lys154 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | E3 ubiquitin-protein ligase MARCHF1, EC:2.3.2.27, MARCH-I, MARCH1, MARCHF1, Membrane-associated RING finger protein 1, Membrane-associated RING-CH protein I, RING finger protein 171, RING-type E3 ubiquitin transferase MARCHF1, RNF171 |
| 背景 | E3 ubiquitin-protein ligase MARCHF1 is a ~32 kDa protein. E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Also regulates insulin sensitivity by controlling surface expression of the insulin receptor subunit beta/INSR by direct ubiquitination and degradation. 1. Thibodeau, J. et al. (2008) European journal of immunology 38, 1225-30. PMID: 18389477 2. De Gassart, A. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 3491-6. PMID: 18305173 3. Tze, LE. et al. (2011) The Journal of experimental medicine 208, 149-65. PMID: 21220452 4. Martin, M. et al. (2022) Journal of virology 96, e0180621. PMID: 35045264 5. Nagarajan, A. et al. (2016) Nature communications 7, 12639. PMID: 27577745 |
| 注意事項 | For research use only |
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