Human MBD5 Recombinant Protein (N-His) (HC714012)

Name: Human MBD5 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC714012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HC714012
Description	Recombinant Human MBD5 Protein, N-His (HC714012) expressed in E. coli, spanning Thr1382-Arg1494. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q9P267
Longueur de protéine	Thr1382-Arg1494
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	15.19 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	KIAA1461, MBD5, Methyl-CpG-binding domain protein 5, Methyl-CpG-binding protein MBD5
Contexte	Methyl-CpG-binding domain protein 5 is a ~159 kDa protein. Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. 1. Baymaz, HI. et al. (2014) Proteomics 14, 2179-89. PMID: 24634419 2. Tsuboyama, N. et al. (2022) Genome biology 23, 206. PMID: 36180891 3. Laget, S. et al. (2010) PloS one 5, e11982. PMID: 20700456
Note	For research use only

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Human MBD5 Recombinant Protein (N-His).pdf

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