Human MBD5 Recombinant Protein (N-His) (HC714012)

Name: Human MBD5 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC714012
Price: 211 USD
Availability: InStock

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概要

カタログ番号	HC714012
説明	Recombinant Human MBD5 Protein, N-His (HC714012) expressed in E. coli, spanning Thr1382-Arg1494. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	E. coli
アクセッション番号	Q9P267
タンパク質長	Thr1382-Arg1494
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	15.19 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	KIAA1461, MBD5, Methyl-CpG-binding domain protein 5, Methyl-CpG-binding protein MBD5
背景	Methyl-CpG-binding domain protein 5 is a ~159 kDa protein. Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. 1. Baymaz, HI. et al. (2014) Proteomics 14, 2179-89. PMID: 24634419 2. Tsuboyama, N. et al. (2022) Genome biology 23, 206. PMID: 36180891 3. Laget, S. et al. (2010) PloS one 5, e11982. PMID: 20700456
注意事項	For research use only

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参考文献

データシート

Human MBD5 Recombinant Protein (N-His).pdf

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Human MBD5 Recombinant Protein (N-His) (HC714012)

概要

イメージ

参考文献

データシート

SDS

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