Human MBL-2 Recombinant Protein (N-His) (HY274042)

Name: Human MBL-2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HY274042
Price: 211 USD
Availability: InStock

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Número de catálogo	HY274042
Descripción	Recombinant Human MBL2 Protein, N-His (HY274042) expressed in E. coli, spanning Gly131-Ile248. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	P11226
Longitud de proteína	Gly131-Ile248
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	15.25 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	COLEC1, Collectin-1, MBL, MBL2, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C
Fondo	Mannose-binding protein C is a ~26 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. May bind DNA. 1. Nauta, AJ. et al. (2003) European journal of immunology 33, 2853-63. PMID: 14515269 2. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085 3. Sheriff, S. et al. (1994) Nature structural biology 1, 789-94. PMID: 7634089 4. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411 5. Super, M. et al. (1989) Lancet (London, England) 2, 1236-9. PMID: 2573758 6. Kawasaki, N. et al. (1983) Journal of biochemistry 94, 937-47. PMID: 6643429 7. van Emmerik, LC. et al. (1994) Clinical and experimental immunology 97, 411-6. PMID: 8082295 8. Stravalaci, M. et al. (2022) Nature immunology 23, 275-286. PMID: 35102342
Nota	For research use only