Human MBL-2 Recombinant Protein (N-His) (HY274042)

Name: Human MBL-2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HY274042
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Каталожный номер	HY274042
Описание	Recombinant Human MBL2 Protein, N-His (HY274042) expressed in E. coli, spanning Gly131-Ile248. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P11226
Длина белка	Gly131-Ile248
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	15.25 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	COLEC1, Collectin-1, MBL, MBL2, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, Mannose-binding protein C
Фон	Mannose-binding protein C is a ~26 kDa protein. Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response. May bind DNA. 1. Nauta, AJ. et al. (2003) European journal of immunology 33, 2853-63. PMID: 14515269 2. Degn, SE. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 3957-69. PMID: 22966085 3. Sheriff, S. et al. (1994) Nature structural biology 1, 789-94. PMID: 7634089 4. Thiel, S. et al. (1997) Nature 386, 506-10. PMID: 9087411 5. Super, M. et al. (1989) Lancet (London, England) 2, 1236-9. PMID: 2573758 6. Kawasaki, N. et al. (1983) Journal of biochemistry 94, 937-47. PMID: 6643429 7. van Emmerik, LC. et al. (1994) Clinical and experimental immunology 97, 411-6. PMID: 8082295 8. Stravalaci, M. et al. (2022) Nature immunology 23, 275-286. PMID: 35102342
Примечание	For research use only