中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HA053012 |
|---|---|
| 説明 |
Recombinant Human MCOLN3 Protein, N-His (HA053012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q8TDD5 |
| タンパク質長 | Asn84-His283 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 25.56 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | MCOLN3, Mucolipin-3, TRPML3, Transient receptor potential channel mucolipin 3 |
| 背景 | Mucolipin-3 is a ~64 kDa protein. Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Also permeable to Mg(2+), Na(+) and K(+). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. 1. Kim, HJ. et al. (2008) The EMBO journal 27, 1197-205. PMID: 18369318 2. Martina, JA. et al. (2009) Traffic (Copenhagen, Denmark) 10, 1143-56. PMID: 19497048 3. Kim, HJ. et al. (2009) Traffic (Copenhagen, Denmark) 10, 1157-67. PMID: 19522758 4. Curcio-Morelli, C. et al. (2010) Journal of cellular physiology 222, 328-35. PMID: 19885840 5. Zhou, X. et al. (2017) Nature structural & molecular biology 24, 1146-1154. PMID: 29106414 6. Lelouvier, B. et al. (2011) The Journal of biological chemistry 286, 9826-32. PMID: 21245134 7. Guo, Z. et al. (2013) PloS one 8, e58174. PMID: 23469151 |
| 注意事項 | For research use only |
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
