Human Methionine synthase/MTR Recombinant Protein (N-His) (HC238012)

Name: Human Methionine synthase/MTR Recombinant Protein (N-His)
Brand: abinScience
SKU: HC238012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HC238012
Description	Recombinant Human Methionine synthase/MTR Protein, N-His (HC238012) expressed in E. coli, spanning Leu924-Asp1265. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q99707
Longueur de protéine	Leu924-Asp1265
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	41.23 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	5-methyltetrahydrofolate--homocysteine methyltransferase, Cobalamin-dependent methionine synthase, EC:2.1.1.13, MS, MTR, Methionine synthase, Vitamin-B12 dependent methionine synthase
Contexte	Methionine synthase is a ~140 kDa protein. Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. 1. Yamada, K. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 9476-81. PMID: 16769880 2. Wolthers, KR. et al. (2007) The FEBS journal 274, 738-50. PMID: 17288554 3. Bassila, C. et al. (2017) Biochimica et biophysica acta. Molecular basis of disease 1863, 103-112. PMID: 27771510
Note	For research use only

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Human Methionine synthase/MTR Recombinant Protein (N-His).pdf

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