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| カタログ番号 | HD847012 |
|---|---|
| 説明 |
Recombinant Human MLLT1 Protein, N-His (HD847012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q03111 |
| タンパク質長 | Met1-Pro145 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | ENL, Eleven-nineteen-leukeumia, LTG19, MLLT1, Protein ENL, YEATS domain-containing protein 1, YEATS1 |
| 背景 | Protein ENL is a ~62 kDa protein. Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated. Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20). May play a role in leukemogenic gene transcription. 1. Lin, C. et al. (2010) Molecular cell 37, 429-37. PMID: 20159561 2. He, N. et al. (2010) Molecular cell 38, 428-38. PMID: 20471948 3. Li, Y. et al. (2016) Molecular cell 62, 181-193. PMID: 27105114 4. Becht, DC. et al. (2025) Nature structural & molecular biology 32, 709-718. PMID: 39794553 |
| 注意事項 | For research use only |
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