Human MOV10 Recombinant Protein (N-His) (HC181012)

Name: Human MOV10 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC181012
Price: 211 USD
Availability: InStock

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Número de catálogo	HC181012
Descripción	Recombinant Human MOV10 Protein, N-His (HC181012) expressed in E. coli, spanning Glu498-Arg733. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q9HCE1
Longitud de proteína	Glu498-Arg733
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	28.50 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Armitage homolog, EC:3.6.4.13, Helicase MOV-10, KIAA1631, MOV10, Moloney leukemia virus 10 protein
Fondo	Helicase MOV-10 is a ~113 kDa protein. 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Blocks HIV-1 virus replication at a post-entry step. Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway. 1. Goodier, JL. et al. (2012) PLoS genetics 8, e1002941. PMID: 23093941 2. Cuevas, RA. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3877-86. PMID: 27016603 3. Balinsky, CA. et al. (2017) Journal of virology 91. PMID: 27974568 4. Yang, X. et al. (2022) PLoS pathogens 18, e1010301. PMID: 35157734 5. Wang, X. et al. (2010) The Journal of biological chemistry 285, 14346-55. PMID: 20215113 6. Chen, C. et al. (2017) Retrovirology 14, 56. PMID: 29258557 7. Liu, T. et al. (2019) The Journal of biological chemistry 294, 19804-19813. PMID: 31722967 8. Gregersen, LH. et al. (2014) Molecular cell 54, 573-85. PMID: 24726324 10. Chendrimada, TP. et al. (2007) Nature 447, 823-8. PMID: 17507929
Nota	For research use only

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Datasheet

Human MOV10 Recombinant Protein (N-His).pdf

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