Human MOV10 Recombinant Protein (N-His) (HC181012)

Name: Human MOV10 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC181012
Price: 211 USD
Availability: InStock

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概要

カタログ番号	HC181012
説明	Recombinant Human MOV10 Protein, N-His (HC181012) expressed in E. coli, spanning Glu498-Arg733. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	E. coli
アクセッション番号	Q9HCE1
タンパク質長	Glu498-Arg733
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	28.50 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	Armitage homolog, EC:3.6.4.13, Helicase MOV-10, KIAA1631, MOV10, Moloney leukemia virus 10 protein
背景	Helicase MOV-10 is a ~113 kDa protein. 5' to 3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Blocks HIV-1 virus replication at a post-entry step. Counteracts HIV-1 Vif-mediated degradation of APOBEC3G through its helicase activity by interfering with the ubiquitin-proteasome pathway. 1. Goodier, JL. et al. (2012) PLoS genetics 8, e1002941. PMID: 23093941 2. Cuevas, RA. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 3877-86. PMID: 27016603 3. Balinsky, CA. et al. (2017) Journal of virology 91. PMID: 27974568 4. Yang, X. et al. (2022) PLoS pathogens 18, e1010301. PMID: 35157734 5. Wang, X. et al. (2010) The Journal of biological chemistry 285, 14346-55. PMID: 20215113 6. Chen, C. et al. (2017) Retrovirology 14, 56. PMID: 29258557 7. Liu, T. et al. (2019) The Journal of biological chemistry 294, 19804-19813. PMID: 31722967 8. Gregersen, LH. et al. (2014) Molecular cell 54, 573-85. PMID: 24726324 10. Chendrimada, TP. et al. (2007) Nature 447, 823-8. PMID: 17507929
注意事項	For research use only

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Human MOV10 Recombinant Protein (N-His).pdf

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Human MOV10 Recombinant Protein (N-His) (HC181012)

概要

イメージ

参考文献

データシート

SDS

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