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Human MYSM1 Recombinant Protein (N-His) (HD302012)

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Vista general
Número de catálogoHD302012
Descripción
Recombinant Human MYSM1 Protein, N-His (HD302012) expressed in E. coli, spanning Asp557-Met828. Purity: >90% by SDS-PAGE.
Highlights
  • ●His-Tagged — N-terminal 6×His tag for IMAC purification.
  • ●E. coli Expression — High-yield, cost-effective production.
  • ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresiónE. coli
Número de accesoQ5VVJ2
Longitud de proteínaAsp557-Met828
AplicacionesELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
EspeciesHomo sapiens (Human)
Naturaleza Recombinant
Nivel de endotoxinas Please contact with the lab for this information.
Pureza >90% as determined by SDS-PAGE.
Peso molecular predicho 33.35 kDa
Forma Lyophilized
Buffer de almacenamiento Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Reconstitución Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos2A-DUB, Deubiquitinase MYSM1, EC:3.4.19.-, KIAA1915, MYSM1, Myb-like, SWIRM and MPN domain-containing protein 1
Fondo

Deubiquitinase MYSM1 is a ~95 kDa protein. Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component.

1. Nandakumar, V. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, E3927-36. PMID: 24062447
2. Le Guen, T. et al. (2015) The Journal of allergy and clinical immunology 136, 1619-1626.e5. PMID: 26220525
3. Bahrami, E. et al. (2017) The Journal of allergy and clinical immunology 140, 1112-1119. PMID: 28115216
4. Tian, M. et al. (2020) Cell reports 33, 108297. PMID: 33086059
5. Zhu, P. et al. (2007) Molecular cell 27, 609-21. PMID: 17707232
Nota For research use only
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Referencias
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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