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| カタログ番号 | HD302012 |
|---|---|
| 説明 |
Recombinant Human MYSM1 Protein, N-His (HD302012) expressed in E. coli, spanning Asp557-Met828. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q5VVJ2 |
| タンパク質長 | Asp557-Met828 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 33.35 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 2A-DUB, Deubiquitinase MYSM1, EC:3.4.19.-, KIAA1915, MYSM1, Myb-like, SWIRM and MPN domain-containing protein 1 |
| 背景 | Deubiquitinase MYSM1 is a ~95 kDa protein. Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. 1. Nandakumar, V. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, E3927-36. PMID: 24062447 2. Le Guen, T. et al. (2015) The Journal of allergy and clinical immunology 136, 1619-1626.e5. PMID: 26220525 3. Bahrami, E. et al. (2017) The Journal of allergy and clinical immunology 140, 1112-1119. PMID: 28115216 4. Tian, M. et al. (2020) Cell reports 33, 108297. PMID: 33086059 5. Zhu, P. et al. (2007) Molecular cell 27, 609-21. PMID: 17707232 |
| 注意事項 | For research use only |
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