Human NBR1 Recombinant Protein (N-His) (HC166012)

Name: Human NBR1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC166012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HC166012
Description	Recombinant Human NBR1 Protein, N-His (HC166012) expressed in E. coli, spanning Ser372-Asp479. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q14596
Longueur de protéine	Ser372-Asp479
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	14.36 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	1A13B, Cell migration-inducing gene 19 protein, KIAA0049, M17S2, Membrane component chromosome 17 surface marker 2, NBR1, Neighbor of BRCA1 gene 1 protein, Next to BRCA1 gene 1 protein, Protein 1A1-3B
Contexte	Next to BRCA1 gene 1 protein is a ~107 kDa protein. Ubiquitin-binding autophagy adapter that participates in different processes including host defense or intracellular homeostasis. Possesses a double function during the selective autophagy by acting as a shuttle bringing ubiquitinated proteins to autophagosomes and also by participating in the formation of protein aggregates. Plays a role in the regulation of the innate immune response by modulating type I interferon production and targeting ubiquitinated IRF3 for autophagic degradation. In response to oxidative stress, promotes an increase in SQSTM1 levels, phosphorylation, and body formation by preventing its autophagic degradation. In turn, activates the KEAP1-NRF2/NFE2L2 antioxidant pathway. 1. Walinda, E. et al. (2014) The Journal of biological chemistry 289, 13890-902. PMID: 24692539 2. Zeng, Y. et al. (2021) PLoS pathogens 17, e1009300. PMID: 33577621 3. Nicot, AS. et al. (2014) Autophagy 10, 1036-53. PMID: 24879152 4. Turco, E. et al. (2021) Nature communications 12, 5212. PMID: 34471133 5. Song, H. et al. (2024) International journal of biological sciences 20, 701-717. PMID: 38169523 6. Cai, Y. et al. (2022) Biochemical and biophysical research communications 623, 140-147. PMID: 35914352
Note	For research use only

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Human NBR1 Recombinant Protein (N-His).pdf

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