

| Numéro de catalogue | HD230012 |
|---|---|
| Description |
Recombinant Human NCAPD2 Protein, N-His (HD230012) expressed in E. coli, spanning Met1-Thr400. Purity: >90% by SDS-PAGE.
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | Q15021 |
| Longueur de protéine | Met1-Thr400 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Homo sapiens (Human) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Masse moléculaire prédite | 47.27 kDa |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | CAPD2, CNAP1, Chromosome condensation-related SMC-associated protein 1, Chromosome-associated protein D2, Condensin complex subunit 1, KIAA0159, NCAPD2, Non-SMC condensin I complex subunit D2, XCAP-D2 homolog, hCAP-D2 |
| Contexte | Condensin complex subunit 1 is a ~157 kDa protein. Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. 1. Kimura, K. et al. (2001) The Journal of biological chemistry 276, 5417-20. PMID: 11136719 2. Martin, CA. et al. (2016) Genes & development 30, 2158-2172. PMID: 27737959 |
| Note | For research use only |
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