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| カタログ番号 | HD102012 |
|---|---|
| 説明 |
Recombinant Human NLRP12 Protein, N-His (HD102012) expressed in E. coli, spanning Gln634-Cys1061. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P59046 |
| タンパク質長 | Gln634-Cys1061 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 49.44 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Monarch-1, NACHT, LRR and PYD domains-containing protein 12, NALP12, NLRP12, PYPAF7, PYRIN-containing APAF1-like protein 7, RNO, Regulated by nitric oxide |
| 背景 | NACHT, LRR and PYD domains-containing protein 12 is a ~120 kDa protein. Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation. 1. Normand, S. et al. (2018) Nature communications 9, 5338. PMID: 30559449 2. Gerhard, DS. et al. (2004) Genome research 14, 2121-7. PMID: 15489334 3. Arthur, JC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 6291-6. PMID: 17947705 4. Chen, ST. et al. (2019) Cell host & microbe 25, 602-616.e7. PMID: 30902577 |
| 注意事項 | For research use only |
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