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| カタログ番号 | HD442012 |
|---|---|
| 説明 |
Recombinant Human NMI Protein, N-His (HD442012) expressed in E. coli, spanning Phe58-Glu307. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q13287 |
| タンパク質長 | Phe58-Glu307 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 30.64 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | N-myc and STAT interactor, N-myc-interactor, NMI, Nmi |
| 背景 | N-myc-interactor is a ~35 kDa protein. Acts as a signaling pathway regulator involved in innate immune system response. In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis. Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription. In response to interferon IFN-alpha, associates in a complex with signaling pathway regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35. In complex with IFI35, inhibits virus-triggered type I IFN-beta production when ubiquitinated by ubiquitin-protein ligase TRIM21. 1. Das, A. et al. (2015) Virology 485, 383-92. PMID: 26342464 2. Xiahou, Z. et al. (2017) Nature communications 8, 950. PMID: 29038465 3. Jian, D. et al. (2018) Acta physiologica (Oxford, England) 223, e13037. PMID: 29350881 4. Zhu, M. et al. (1999) Cell 96, 121-30. PMID: 9989503 5. Feng, L. et al. (2018) PLoS pathogens 14, e1006867. PMID: 29377960 6. Zhou, X. et al. (2000) The Journal of biological chemistry 275, 21364-71. PMID: 10779520 7. Chen, J. et al. (2000) The Journal of biological chemistry 275, 36278-84. PMID: 10950963 |
| 注意事項 | For research use only |
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