

| Número de catálogo | HE005012 |
|---|---|
| Descripción |
Recombinant Human NPLOC4 Protein, N-His (HE005012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Sistema de expresión | E. coli |
| Número de acceso | Q8TAT6 |
| Longitud de proteína | Arg221-Thr608 |
| Aplicaciones | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Especies | Homo sapiens (Human) |
| Naturaleza | Recombinant |
| Nivel de endotoxinas | Please contact with the lab for this information. |
| Pureza | >90% as determined by SDS-PAGE. |
| Forma | Lyophilized |
| Buffer de almacenamiento | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
| Reconstitución | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Envío | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Nombres alternativos | KIAA1499, NPL4, NPLOC4, Nuclear protein localization protein 4 homolog, Protein NPL4 |
| Fondo | Nuclear protein localization protein 4 homolog is a ~68 kDa protein. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI. 1. Hao, Q. et al. (2015) The EMBO journal 34, 2903-20. PMID: 26471729 |
| Nota | For research use only |
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