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| カタログ番号 | HD896012 |
|---|---|
| 説明 |
Recombinant Human NR4A3 Protein, N-His (HD896012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q92570 |
| タンパク質長 | Ile396-Phe626 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CHN, CSMF, MINOR, Mitogen-induced nuclear orphan receptor, NOR1, NR4A3, Neuron-derived orphan receptor 1, Nuclear hormone receptor NOR-1, Nuclear receptor subfamily 4 group A member 3, TEC, Translocated in extraskeletal chondrosarcoma |
| 背景 | Nuclear receptor subfamily 4 group A member 3 is a ~68 kDa protein. Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes. Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site. Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. 1. Zhao, Y. et al. (2010) Circulation research 107, 501-11. PMID: 20558821 2. Liu, Q. et al. (2013) American journal of physiology. Endocrinology and metabolism 305, E1081-92. PMID: 24022864 |
| 注意事項 | For research use only |
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