Human NRDE2 Recombinant Protein (N-His) (HP300022)

Name: Human NRDE2 Recombinant Protein (N-His)
Brand: abinScience
SKU: HP300022
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HP300022
Description	Recombinant Human NRDE2 Protein, N-His (HP300022) expressed in E. coli, spanning Thr162-Thr266. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q9H7Z3
Longueur de protéine	Thr162-Thr266
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	14.17 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	C14orf102, NRDE2, Nuclear exosome regulator NRDE2, Protein NRDE2 homolog
Contexte	Nuclear exosome regulator NRDE2 is a ~132 kDa protein. Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation. Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation. Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome. By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm. U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis. 1. Wang, J. et al. (2019) Genes & development 33, 536-549. PMID: 30842217 2. Jiao, AL. et al. (2019) RNA (New York, N.Y.) 25, 352-363. PMID: 30538148 3. Richard, P. et al. (2018) RNA biology 15, 868-876. PMID: 29902117
Note	For research use only

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Human NRDE2 Recombinant Protein (N-His).pdf

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