Human NRG1 Recombinant Protein (C-Fc) (HX096041)

Name: Human NRG1 Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HX096041
Price: 298 USD
Availability: InStock

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50ug
100ug
1mg

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概要
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参考文献
データシート
SDS

概要

カタログ番号	HX096041
説明	Recombinant Human NRG1 Protein, C-Fc (HX096041) expressed in Mammalian Cells, spanning Lys22-Lys241. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
発現システム	Mammalian cells
アクセッション番号	Q02297
タンパク質長	Lys22-Lys241
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
予測分子量	52.23 kDa
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	ARIA, Acetylcholine receptor-inducing activity, Breast cancer cell differentiation factor p45, GGF, Glial growth factor, HGL, HRG, HRGA, Heregulin, NDF, NRG1, Neu differentiation factor, Neuregulin-1, Pro-NRG1, Pro-neuregulin-1, membrane-bound isoform, SMDF, Sensory and motor neuron-derived factor
背景	Pro-neuregulin-1, membrane-bound isoform is a ~70 kDa protein. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4. 1. Sweeney, C. et al. (2000) The Journal of biological chemistry 275, 19803-7. PMID: 10867024 2. Plowman, GD. et al. (1993) Nature 366, 473-5. PMID: 7902537 3. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778
注意事項	For research use only

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Bioactivity

Immobilized HB116011 Human ERBB3/HER3 Recombinant Protein (C-His) at 2 μg/mL(100 μL/well) can bind HX096041 Human NRG1 Recombinant Protein (C-Fc), the EC 50 is 1.9 μg/mL.

参考文献

データシート