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| カタログ番号 | HD902012 |
|---|---|
| 説明 |
Recombinant Human NSD2 Protein, N-GST & C-His (HD902012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O96028 |
| タンパク質長 | Asn221-Ala367 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:2.1.1.357, Histone-lysine N-methyltransferase NSD2, KIAA1090, MMSET, Multiple myeloma SET domain-containing protein, NSD2, Nuclear SET domain-containing protein 2, Protein trithorax-5, TRX5, WHSC1, Wolf-Hirschhorn syndrome candidate 1 protein |
| 背景 | Histone-lysine N-methyltransferase NSD2 is a ~152 kDa protein. Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro. Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells. By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes. 1. Li, Y. et al. (2009) The Journal of biological chemistry 284, 34283-95. PMID: 19808676 2. Kuo, AJ. et al. (2011) Molecular cell 44, 609-20. PMID: 22099308 3. Tisi, D. et al. (2016) ACS chemical biology 11, 3093-3105. PMID: 27571355 4. Zhuang, L. et al. (2018) Nature communications 9, 1796. PMID: 29728617 5. Zanoni, P. et al. (2021) Genetics in medicine : official journal of the American College of Medical Genetics 23, 1474-1483. PMID: 33941880 6. Hudlebusch, HR. et al. (2005) British journal of haematology 130, 700-8. PMID: 16115125 |
| 注意事項 | For research use only |
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