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| カタログ番号 | HD051012 |
|---|---|
| 説明 |
Recombinant Human NUDT1 Protein, N-His (HD051012) expressed in E. coli, spanning Glu43-Val156. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P36639 |
| タンパク質長 | Glu43-Val156 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 15.69 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 2-hydroxy-dATP diphosphatase, 7,8-dihydro-8-oxoguanine triphosphatase, 8-oxo-dGTPase, EC:3.6.1.-, EC:3.6.1.56, MTH1, Methylated purine nucleoside triphosphate hydrolase, NUDT1, Nucleoside diphosphate-linked moiety X motif 1, Nudix motif 1, Oxidized purine nucleoside triphosphate hydrolase |
| 背景 | Oxidized purine nucleoside triphosphate hydrolase is a ~17 kDa protein. Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. 1. Fujii, Y. et al. (1999) The Journal of biological chemistry 274, 38251-9. PMID: 10608900 2. Yoshimura, D. et al. (2003) The Journal of biological chemistry 278, 37965-73. PMID: 12857738 3. Takagi, Y. et al. (2012) The Journal of biological chemistry 287, 21541-9. PMID: 22556419 4. Gad, H. et al. (2014) Nature 508, 215-21. PMID: 24695224 5. Huber, KV. et al. (2014) Nature 508, 222-7. PMID: 24695225 6. Carter, M. et al. (2015) Nature communications 6, 7871. PMID: 26238318 7. Ellermann, M. et al. (2017) ACS chemical biology 12, 1986-1992. PMID: 28679043 8. Furuichi, M. et al. (1994) Genomics 24, 485-90. PMID: 7713500 9. Sakumi, K. et al. (1993) The Journal of biological chemistry 268, 23524-30. PMID: 8226881 10. Fujikawa, K. et al. (1999) The Journal of biological chemistry 274, 18201-5. PMID: 10373420 |
| 注意事項 | For research use only |
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