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| カタログ番号 | HE008012 |
|---|---|
| 説明 |
Recombinant Human OCRL Protein, N-His (HE008012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q01968 |
| タンパク質長 | Lys536-Asp901 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:3.1.3.36, EC:3.1.3.56, EC:3.1.3.86, Inositol polyphosphate 5-phosphatase OCRL, Inositol polyphosphate 5-phosphatase OCRL-1, Lowe oculocerebrorenal syndrome protein, OCRL, OCRL-1, OCRL1, Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase |
| 背景 | Inositol polyphosphate 5-phosphatase OCRL is a ~104 kDa protein. Catalyzes the hydrolysis of the 5-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyze the 5-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling. 1. Kisseleva, MV. et al. (2000) The Journal of biological chemistry 275, 20110-6. PMID: 10764818 2. Schmid, AC. et al. (2004) FEBS letters 576, 9-13. PMID: 15474001 3. Zhang, X. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 4853-6. PMID: 7761412 4. Zhang, X. et al. (1998) The Journal of biological chemistry 273, 1574-82. PMID: 9430698 5. Nakatsu, F. et al. (2015) The Journal of cell biology 209, 85-95. PMID: 25869668 6. Vicinanza, M. et al. (2011) The EMBO journal 30, 4970-85. PMID: 21971085 7. Coon, BG. et al. (2012) Human molecular genetics 21, 1835-47. PMID: 22228094 8. Luo, N. et al. (2012) Human molecular genetics 21, 3333-44. PMID: 22543976 9. Bohdanowicz, M. et al. (2012) Molecular biology of the cell 23, 176-87. PMID: 22072788 |
| 注意事項 | For research use only |
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