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| カタログ番号 | HT197022 |
|---|---|
| 説明 |
Recombinant Human PEX1 Protein, N-His (HT197022) expressed in E. coli, spanning Ala15-Ile177. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O43933 |
| タンパク質長 | Ala15-Ile177 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 20.68 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:3.6.4.-, PEX1, Peroxin-1, Peroxisomal ATPase PEX1, Peroxisome biogenesis disorder protein 1, Peroxisome biogenesis factor 1 |
| 背景 | Peroxisomal ATPase PEX1 is a ~142 kDa protein. Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. 1. Tamura, S. et al. (2001) The Biochemical journal 357, 417-26. PMID: 11439091 2. Miyata, N. et al. (2005) Molecular and cellular biology 25, 10822-32. PMID: 16314507 3. Tamura, S. et al. (2006) The Journal of biological chemistry 281, 27693-704. PMID: 16854980 4. Nashiro, C. et al. (2011) Traffic (Copenhagen, Denmark) 12, 774-88. PMID: 21362118 5. Pedrosa, AG. et al. (2018) The Journal of biological chemistry 293, 11553-11563. PMID: 29884772 |
| 注意事項 | For research use only |
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