Human PHF19 Recombinant Protein (N-His) (HC221012)

Name: Human PHF19 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC221012
Price: 211 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	HC221012
Описание	Recombinant Human PHF19 Protein, N-His (HC221012) expressed in E. coli, spanning Asn22-Lys350. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q5T6S3
Длина белка	Asn22-Lys350
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	40.20 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	PCL3, PHD finger protein 19, PHF19, Polycomb-like protein 3, hPCL3
Фон	PHD finger protein 19 is a ~65 kDa protein. Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter. 1. Wang, S. et al. (2004) Gene 343, 69-78. PMID: 15563832 2. Daub, H. et al. (2008) Molecular cell 31, 438-48. PMID: 18691976 3. Ballaré, C. et al. (2012) Nature structural & molecular biology 19, 1257-65. PMID: 23104054 4. Brien, GL. et al. (2012) Nature structural & molecular biology 19, 1273-81. PMID: 23160351 5. Qin, S. et al. (2013) Biochemical and biophysical research communications 430, 547-53. PMID: 23228662 6. Cai, L. et al. (2013) Molecular cell 49, 571-82. PMID: 23273982 7. Chen, S. et al. (2018) Molecular cell 69, 840-852.e5. PMID: 29499137 8. Chen, S. et al. (2020) Molecular cell 77, 1265-1278.e7. PMID: 31959557
Примечание	For research use only

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Human PHF19 Recombinant Protein (N-His).pdf

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