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| カタログ番号 | HW703022 |
|---|---|
| 説明 |
Recombinant Human PIK3CB/p110beta Protein, N-His (HW703022) expressed in E. coli, spanning Trp327-Gly701. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P42338 |
| タンパク質長 | Trp327-Gly701 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 45.59 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | EC:2.7.1.153, EC:2.7.11.1, PI3-kinase subunit beta, PI3K-beta, PI3Kbeta, PIK3C1, PIK3CB, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, PtdIns-3-kinase subunit beta, PtdIns-3-kinase subunit p110-beta, Serine/threonine protein kinase PIK3CB, p110beta |
| 背景 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform is a ~122 kDa protein. Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. 1. Meier, TI. et al. (2004) Protein expression and purification 35, 218-24. PMID: 15135396 2. Czupalla, C. et al. (2003) The Journal of biological chemistry 278, 11536-45. PMID: 12502714 |
| 注意事項 | For research use only |
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