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| カタログ番号 | HC792012 |
|---|---|
| 説明 |
Recombinant Human PLXNB2 Protein, N-His (HC792012) expressed in E. coli, spanning Gln56-Gly225. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | O15031 |
| タンパク質長 | Gln56-Gly225 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 20.74 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | KIAA0315, MM1, PLXNB2, Plexin-B2 |
| 背景 | Plexin-B2 is a ~205 kDa protein. Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. 1. Yu, W. et al. (2017) Cell 171, 849-864.e25. PMID: 29100074 2. Bai, R. et al. (2020) The EMBO journal 39, e103325. PMID: 32510170 3. Perrot, V. et al. (2002) The Journal of biological chemistry 277, 43115-20. PMID: 12183458 4. Conrotto, P. et al. (2004) Oncogene 23, 5131-7. PMID: 15184888 |
| 注意事項 | For research use only |
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