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| カタログ番号 | HD852012 |
|---|---|
| 説明 |
Recombinant Human POLE Protein, N-His (HD852012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q07864 |
| タンパク質長 | Ser30-Lys495 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | 3'-5' exodeoxyribonuclease, DNA polymerase II subunit A, DNA polymerase epsilon catalytic subunit A, EC:2.7.7.7, EC:3.1.11.-, POLE, POLE1 |
| 背景 | DNA polymerase epsilon catalytic subunit A is a ~261 kDa protein. Catalytic component of the DNA polymerase epsilon complex. Participates in chromosomal DNA replication. Required during synthesis of the leading DNA strands at the replication fork, binds at/or near replication origins and moves along DNA with the replication fork. Has 3'-5' proofreading exonuclease activity that corrects errors arising during DNA replication. Involved in DNA synthesis during DNA repair. 1. Li, Y. et al. (2000) The Journal of biological chemistry 275, 23247-52. PMID: 10801849 2. Ogi, T. et al. (2010) Molecular cell 37, 714-27. PMID: 20227374 3. Wimmer, K. et al. (2017) Familial cancer 16, 67-71. PMID: 27573199 |
| 注意事項 | For research use only |
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