

| Número de catálogo | HD625012 |
|---|---|
| Descripción |
Recombinant Human PPP1R11 Protein, N-His-KSI (HD625012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Sistema de expresión | E. coli |
| Número de acceso | O60927 |
| Longitud de proteína | Arg26-His126 |
| Aplicaciones | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Especies | Homo sapiens (Human) |
| Naturaleza | Recombinant |
| Nivel de endotoxinas | Please contact with the lab for this information. |
| Pureza | >90% as determined by SDS-PAGE. |
| Forma | Lyophilized |
| Buffer de almacenamiento | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
| Reconstitución | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Envío | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Nombres alternativos | E3 ubiquitin-protein ligase PPP1R11, EC:2.3.2.27, HCG V, HCGV, Hemochromatosis candidate gene V protein, PPP1R11, Protein phosphatase 1 regulatory subunit 11, Protein phosphatase inhibitor 3, TCTE5 |
| Fondo | E3 ubiquitin-protein ligase PPP1R11 is a ~13 kDa protein. Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1. 1. McKelvey, AC. et al. (2016) eLife 5. PMID: 27805901 2. Zhang, J. et al. (1998) Biochemistry 37, 16728-34. PMID: 9843442 |
| Nota | For research use only |
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