Human PRKACB Recombinant Protein (N-His) (HD981012)

Name: Human PRKACB Recombinant Protein (N-His)
Brand: abinScience
SKU: HD981012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Обзор

Каталожный номер	HD981012
Описание	Recombinant Human PRKACB Protein, N-His (HD981012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P22694
Длина белка	Met1-Phe351
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	EC:2.7.11.11, PKA C-beta, PRKACB, cAMP-dependent protein kinase catalytic subunit beta
Фон	cAMP-dependent protein kinase catalytic subunit beta is a ~40 kDa protein. Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR. 1. Wu, KJ. et al. (2002) Oncogene 21, 7872-82. PMID: 12420224 2. Lignitto, L. et al. (2011) Nature cell biology 13, 412-22. PMID: 21423175 3. Jewell, JL. et al. (2019) eLife 8. PMID: 31112131 4. Aksaas, AK. et al. (2011) Journal of molecular signaling 6, 10. PMID: 21880142
Примечание	For research use only

Изображения

Ссылки

Даташит

Human PRKACB Recombinant Protein (N-His).pdf

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Formula

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C₁ (Stock Conc.)

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Working Solution

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