Human PRKDC Recombinant Protein (N-His) (HD935012)

Name: Human PRKDC Recombinant Protein (N-His)
Brand: abinScience
SKU: HD935012
Price: 211 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HD935012
Description	Recombinant Human PRKDC Protein, N-His (HD935012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	P78527
Longueur de protéine	Arg1816-Pro2202
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	DNA-PK catalytic subunit, DNA-PKcs, DNA-dependent protein kinase catalytic subunit, DNPK1, EC:2.7.11.1, HYRC, HYRC1, PRKDC, S473K, Ser-473 kinase, p460
Contexte	DNA-dependent protein kinase catalytic subunit is a ~469 kDa protein. Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ. 1. Ma, Y. et al. (2002) Cell 108, 781-94. PMID: 11955432 2. Soubeyrand, S. et al. (2003) Cancer research 63, 1198-201. PMID: 12649176 3. Wechsler, T. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 1247-52. PMID: 14734805 4. Chen, S. et al. (2021) Nature 593, 294-298. PMID: 33854234 5. Chaplin, AK. et al. (2021) Molecular cell 81, 3400-3409.e3. PMID: 34352203
Note	For research use only

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Human PRKDC Recombinant Protein (N-His).pdf

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