Human PRKDC Recombinant Protein (N-His) (HD935012)

Name: Human PRKDC Recombinant Protein (N-His)
Brand: abinScience
SKU: HD935012
Price: 211 USD
Availability: InStock

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1mg

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Каталожный номер	HD935012
Описание	Recombinant Human PRKDC Protein, N-His (HD935012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P78527
Длина белка	Arg1816-Pro2202
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	DNA-PK catalytic subunit, DNA-PKcs, DNA-dependent protein kinase catalytic subunit, DNPK1, EC:2.7.11.1, HYRC, HYRC1, PRKDC, S473K, Ser-473 kinase, p460
Фон	DNA-dependent protein kinase catalytic subunit is a ~469 kDa protein. Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). Recruited by XRCC5 and XRCC6 to DNA ends and is required to (1) protect and align broken ends of DNA, thereby preventing their degradation, (2) and sequester the DSB for repair by NHEJ. 1. Ma, Y. et al. (2002) Cell 108, 781-94. PMID: 11955432 2. Soubeyrand, S. et al. (2003) Cancer research 63, 1198-201. PMID: 12649176 3. Wechsler, T. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 1247-52. PMID: 14734805 4. Chen, S. et al. (2021) Nature 593, 294-298. PMID: 33854234 5. Chaplin, AK. et al. (2021) Molecular cell 81, 3400-3409.e3. PMID: 34352203
Примечание	For research use only

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Даташит

Human PRKDC Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Volume

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g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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