Human QRICH1 Recombinant Protein (N-His) (HD267012)

Name: Human QRICH1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD267012
Price: 211 USD
Availability: InStock

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100ug
1mg

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Vista general

Número de catálogo	HD267012
Descripción	Recombinant Human QRICH1 Protein, N-His (HD267012) expressed in E. coli, spanning Leu473-His776. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q2TAL8
Longitud de proteína	Leu473-His776
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	37.59 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	Glutamine-rich protein 1, QRICH1, Transcriptional regulator QRICH1
Fondo	Transcriptional regulator QRICH1 is a ~86 kDa protein. Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. 1. You, K. et al. (2021) Science (New York, N.Y.) 371. PMID: 33384352 2. Zhang, L. et al. (2025) Molecular medicine (Cambridge, Mass.) 31, 183. PMID: 40355839 3. Bianchi, D. et al. (2025) Science (New York, N.Y.) 389, eadv2861. PMID: 40608935 4. Lui, JC. et al. (2019) Clinical genetics 95, 160-164. PMID: 30281152
Nota	For research use only

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Referencias

Datasheet

Human QRICH1 Recombinant Protein (N-His).pdf

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Working Solution

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