Human QRICH1 Recombinant Protein (N-His) (HD267012)

Name: Human QRICH1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD267012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD267012
Description	Recombinant Human QRICH1 Protein, N-His (HD267012) expressed in E. coli, spanning Leu473-His776. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q2TAL8
Longueur de protéine	Leu473-His776
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	37.59 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	Glutamine-rich protein 1, QRICH1, Transcriptional regulator QRICH1
Contexte	Transcriptional regulator QRICH1 is a ~86 kDa protein. Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress. Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway. ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR. May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability. Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. 1. You, K. et al. (2021) Science (New York, N.Y.) 371. PMID: 33384352 2. Zhang, L. et al. (2025) Molecular medicine (Cambridge, Mass.) 31, 183. PMID: 40355839 3. Bianchi, D. et al. (2025) Science (New York, N.Y.) 389, eadv2861. PMID: 40608935 4. Lui, JC. et al. (2019) Clinical genetics 95, 160-164. PMID: 30281152
Note	For research use only

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Human QRICH1 Recombinant Protein (N-His).pdf

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