Human RGS7 Recombinant Protein (N-His) (HW520012)

Name: Human RGS7 Recombinant Protein (N-His)
Brand: abinScience
SKU: HW520012
Price: 211 USD
Availability: InStock

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Número de catálogo	HW520012
Descripción	Recombinant Human RGS7 Protein, N-His (HW520012) expressed in E. coli, spanning Ser18-Arg221. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	P49802
Longitud de proteína	Ser18-Arg221
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	26.20 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	RGS7, Regulator of G-protein signaling 7
Fondo	Regulator of G-protein signaling 7 is a ~57 kDa protein. GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. 1. Posner, BA. et al. (1999) The Journal of biological chemistry 274, 31087-93. PMID: 10521509 2. Benzing, T. et al. (2000) The Journal of biological chemistry 275, 28167-72. PMID: 10862767 3. Hajj, M. et al. (2019) Molecular pharmacology 96, 233-246. PMID: 31189666 4. Hunt, RA. et al. (2003) Biochemical and biophysical research communications 303, 594-9. PMID: 12659861 5. Drenan, RM. et al. (2005) The Journal of cell biology 169, 623-33. PMID: 15897264
Nota	For research use only

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Datasheet

Human RGS7 Recombinant Protein (N-His).pdf

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