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| カタログ番号 | HW520012 |
|---|---|
| 説明 |
Recombinant Human RGS7 Protein, N-His (HW520012) expressed in E. coli, spanning Ser18-Arg221. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P49802 |
| タンパク質長 | Ser18-Arg221 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 26.20 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | RGS7, Regulator of G-protein signaling 7 |
| 背景 | Regulator of G-protein signaling 7 is a ~57 kDa protein. GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form. May play a role in synaptic vesicle exocytosis (Probable). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. 1. Posner, BA. et al. (1999) The Journal of biological chemistry 274, 31087-93. PMID: 10521509 2. Benzing, T. et al. (2000) The Journal of biological chemistry 275, 28167-72. PMID: 10862767 3. Hajj, M. et al. (2019) Molecular pharmacology 96, 233-246. PMID: 31189666 4. Hunt, RA. et al. (2003) Biochemical and biophysical research communications 303, 594-9. PMID: 12659861 5. Drenan, RM. et al. (2005) The Journal of cell biology 169, 623-33. PMID: 15897264 |
| 注意事項 | For research use only |
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