Human RNF144A Recombinant Protein (N-His) (HD794012)

Name: Human RNF144A Recombinant Protein (N-His)
Brand: abinScience
SKU: HD794012
Price: 211 USD
Availability: InStock

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Número de catálogo	HD794012
Descripción	Recombinant Human RNF144A Protein, N-His (HD794012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	P50876
Longitud de proteína	Pro16-Leu236
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	E3 ubiquitin-protein ligase RNF144A, EC:2.3.2.31, KIAA0161, RING finger protein 144A, RNF144, RNF144A, UBCE7IP4, UbcM4-interacting protein 4, Ubiquitin-conjugating enzyme 7-interacting protein 4
Fondo	E3 ubiquitin-protein ligase RNF144A is a ~32 kDa protein. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage. Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways. Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination. Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol. 1. Ho, SR. et al. (2015) The Journal of biological chemistry 290, 23026-38. PMID: 26216882 2. Ho, SR. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E2646-55. PMID: 24979766 3. Yang, B. et al. (2023) EMBO reports 24, e57528. PMID: 37955227 4. Ho, SR. et al. (2018) The Journal of biological chemistry 293, 16307-16323. PMID: 30171075 5. Han, SH. et al. (2020) Journal of cell science 133. PMID: 33067254
Nota	For research use only

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Datasheet

Human RNF144A Recombinant Protein (N-His).pdf

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