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| カタログ番号 | HD794012 |
|---|---|
| 説明 |
Recombinant Human RNF144A Protein, N-His (HD794012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P50876 |
| タンパク質長 | Pro16-Leu236 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | E3 ubiquitin-protein ligase RNF144A, EC:2.3.2.31, KIAA0161, RING finger protein 144A, RNF144, RNF144A, UBCE7IP4, UbcM4-interacting protein 4, Ubiquitin-conjugating enzyme 7-interacting protein 4 |
| 背景 | E3 ubiquitin-protein ligase RNF144A is a ~32 kDa protein. E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage. Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways. Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination. Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol. 1. Ho, SR. et al. (2015) The Journal of biological chemistry 290, 23026-38. PMID: 26216882 2. Ho, SR. et al. (2014) Proceedings of the National Academy of Sciences of the United States of America 111, E2646-55. PMID: 24979766 3. Yang, B. et al. (2023) EMBO reports 24, e57528. PMID: 37955227 4. Ho, SR. et al. (2018) The Journal of biological chemistry 293, 16307-16323. PMID: 30171075 5. Han, SH. et al. (2020) Journal of cell science 133. PMID: 33067254 |
| 注意事項 | For research use only |
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