Human SCAF4 Recombinant Protein (N-His) (HC973012)

Name: Human SCAF4 Recombinant Protein (N-His)
Brand: abinScience
SKU: HC973012
Price: 211 USD
Availability: InStock

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Número de catálogo	HC973012
Descripción	Recombinant Human SCAF4 Protein, N-His (HC973012) expressed in E. coli, spanning Glu501-Lys635. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	O95104
Longitud de proteína	Glu501-Lys635
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	17.66 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CTD-binding SR-like protein RA4, KIAA1172, SCAF4, SFRS15, SR-related and CTD-associated factor 4, Splicing factor, arginine/serine-rich 15
Fondo	SR-related and CTD-associated factor 4 is a ~125 kDa protein. Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough. 1. Gregersen, LH. et al. (2019) Cell 177, 1797-1813.e18. PMID: 31104839
Nota	For research use only

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Datasheet

Human SCAF4 Recombinant Protein (N-His).pdf

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