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| カタログ番号 | HD851012 |
|---|---|
| 説明 |
Recombinant Human SCN1B Protein, N-His (HD851012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q07699 |
| タンパク質長 | Gly19-Lys149 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | SCN1B, Sodium channel regulatory subunit beta-1 |
| 背景 | Sodium channel regulatory subunit beta-1 is a ~24 kDa protein. Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. 1. Qin, N. et al. (2003) European journal of biochemistry 270, 4762-70. PMID: 14622265 2. Spampanato, J. et al. (2004) The Journal of neuroscience : the official journal of the Society for Neuroscience 24, 10022-34. PMID: 15525788 3. Watanabe, H. et al. (2008) The Journal of clinical investigation 118, 2260-8. PMID: 18464934 4. Patino, GA. et al. (2009) The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 10764-78. PMID: 19710327 5. Baroni, D. et al. (2018) Human mutation 39, 1402-1415. PMID: 29992740 6. Fan, X. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2220578120. PMID: 36696443 7. Makita, N. et al. (1994) The Journal of biological chemistry 269, 7571-8. PMID: 8125980 8. McClatchey, AI. et al. (1993) Human molecular genetics 2, 745-9. PMID: 8394762 9. Shen, H. et al. (2019) Science (New York, N.Y.) 363, 1303-1308. PMID: 30765606 |
| 注意事項 | For research use only |
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