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| カタログ番号 | HD952012 |
|---|---|
| 説明 |
Recombinant Human SCNN1B Protein, N-His (HD952012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P51168 |
| タンパク質長 | Ser76-Ala512 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Amiloride-sensitive sodium channel subunit beta, Beta-ENaC, Beta-NaCH, ENaC subunit beta, ENaCB, Epithelial Na(+) channel subunit beta, Epithelial sodium channel subunit beta, Nonvoltage-gated sodium channel 1 subunit beta, SCNEB, SCNN1B |
| 背景 | Epithelial sodium channel subunit beta is a ~72 kDa protein. This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis. ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically. It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys. Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance. 1. Noreng, S. et al. (2018) eLife 7. PMID: 30251954 2. Noreng, S. et al. (2020) eLife 9. PMID: 32729833 3. McDonald, FJ. et al. (1995) The American journal of physiology 268, C1157-63. PMID: 7762608 4. Goulet, CC. et al. (1998) The Journal of biological chemistry 273, 30012-7. PMID: 9792722 5. Hobbs, CA. et al. (2013) American journal of physiology. Lung cellular and molecular physiology 305, L990-L1001. PMID: 24124190 6. Saxena, A. et al. (2002) The Journal of clinical endocrinology and metabolism 87, 3344-50. PMID: 12107247 |
| 注意事項 | For research use only |
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