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| カタログ番号 | HD113012 |
|---|---|
| 説明 |
Recombinant Human SEC61A1 Protein, N-GST & C-His (HD113012) expressed in E. coli, spanning Ser376-Ala420. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P61619 |
| タンパク質長 | Ser376-Ala420 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 33.34 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Protein transport protein Sec61 subunit alpha isoform 1, SEC61A, SEC61A1, Sec61 alpha-1 |
| 背景 | Protein transport protein Sec61 subunit alpha isoform 1 is a ~52 kDa protein. Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. 1. Meacock, SL. et al. (2002) Molecular biology of the cell 13, 4114-29. PMID: 12475939 2. Lang, S. et al. (2012) Journal of cell science 125, 1958-69. PMID: 22375059 3. Schubert, D. et al. (2018) The Journal of allergy and clinical immunology 141, 1427-1438. PMID: 28782633 4. Haßdenteufel, S. et al. (2018) Cell reports 23, 1373-1386. PMID: 29719251 5. Chitwood, PJ. et al. (2020) Nature 584, 630-634. PMID: 32814900 6. McGilvray, PT. et al. (2020) eLife 9. PMID: 32820719 7. Sundaram, A. et al. (2022) Nature 611, 167-172. PMID: 36261522 8. Do, H. et al. (1996) Cell 85, 369-78. PMID: 8616892 |
| 注意事項 | For research use only |
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