Human SEPHS1 Recombinant Protein (N-His) (HW700012)

Name: Human SEPHS1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HW700012
Price: 211 USD
Availability: InStock

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Каталожный номер	HW700012
Описание	Recombinant Human SEPHS1 Protein, N-His (HW700012) expressed in E. coli, spanning Ser2-Ser392. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P49903
Длина белка	Ser2-Ser392
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	45.22 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	EC:2.7.9.3, SELD, SEPHS1, SPS, SPS1, Selenide, water dikinase 1, Selenium donor protein 1, Selenophosphate synthase 1
Фон	Zincore component SEPHS1 is a ~42 kDa protein. Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression. The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif. Within the complex, SEPHS1, recognizes and binds the backbone of zinc fingers of transcription factors in a sequence-independent manner via its arginine clamp, enhancing their DNA-binding stability. Plays an essential role in redox homeostasis. May also be involved in selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP. 1. Bianchi, D. et al. (2025) Science (New York, N.Y.) 389, eadv2861. PMID: 40608935 2. Lee, MO. et al. (2019) Biochemical and biophysical research communications 520, 406-412. PMID: 31607477 3. Low, SC. et al. (1995) The Journal of biological chemistry 270, 21659-64. PMID: 7665581 4. Tamura, T. et al. (2004) Proceedings of the National Academy of Sciences of the United States of America 101, 16162-7. PMID: 15534230
Примечание	For research use only

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Human SEPHS1 Recombinant Protein (N-His).pdf

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