Human SESN1 Recombinant Protein (N-His) (HD946012)

Name: Human SESN1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD946012
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HD946012
Description	Recombinant Human SESN1 Protein, N-His (HD946012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	Q9Y6P5
Longueur de protéine	Glu54-Gly220
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	EC:1.11.1.-, PA26, SESN1, SEST1, Sestrin-1, p53-regulated protein PA26
Contexte	Sestrin-1 is a ~56 kDa protein. Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. 1. Chantranupong, L. et al. (2014) Cell reports 9, 1-8. PMID: 25263562 2. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 3. Bae, SH. et al. (2013) Cell metabolism 17, 73-84. PMID: 23274085 4. Budanov, AV. et al. (2004) Science (New York, N.Y.) 304, 596-600. PMID: 15105503
Note	For research use only

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Human SESN1 Recombinant Protein (N-His).pdf

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