Human SESN1 Recombinant Protein (N-His) (HD946012)

Name: Human SESN1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD946012
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Обзор

Каталожный номер	HD946012
Описание	Recombinant Human SESN1 Protein, N-His (HD946012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	Q9Y6P5
Длина белка	Glu54-Gly220
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	EC:1.11.1.-, PA26, SESN1, SEST1, Sestrin-1, p53-regulated protein PA26
Фон	Sestrin-1 is a ~56 kDa protein. Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. 1. Chantranupong, L. et al. (2014) Cell reports 9, 1-8. PMID: 25263562 2. Wolfson, RL. et al. (2016) Science (New York, N.Y.) 351, 43-8. PMID: 26449471 3. Bae, SH. et al. (2013) Cell metabolism 17, 73-84. PMID: 23274085 4. Budanov, AV. et al. (2004) Science (New York, N.Y.) 304, 596-600. PMID: 15105503
Примечание	For research use only

Изображения

Ссылки

Даташит

Human SESN1 Recombinant Protein (N-His).pdf

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Formula

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C₁ (Stock Conc.)

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